Fibroblast Growth Factor 21 Ameliorates NaV1.5 and Kir2.1 Channel Dysregulation in Human AC16 Cardiomyocytes

Fibroblast Growth Factor 21 Ameliorates NaV1.5 and Kir2.1 Channel Dysregulation in Human AC16 Cardiomyocytes

Infarcted myocardium is predisposed to cause lethal ventricular arrhythmias that remain the main cause of death in patients suffering myocardial ischemia. Liver-derived fibroblast growth factor 21 (FGF21) is an endocrine regulator, which exerts metabolic actions by favoring glucose and lipids metabo...

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Bibliographic Details
Main Authors: Jiamin Li, Yuanshi Li, Yining Liu, Hang Yu, Ning Xu, Di Huang, Yadong Xue, Sijia Li, Haixin Chen, Jiali Liu, Qingsui Li, Yiming Zhao, Ronghao Zhang, Hongru Xue, Yuehang Sun, Ming Li, Pengyu Li, Mingbin Liu, Zhen Zhang, Xin Li, Weijie Du, Ning Wang, Baofeng Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
myocardial infarction
ventricular arrhythmias
ion channel
AC16
action potential duration
FGF21 (fibroblast growth factor 21)
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.715466/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.715466/full

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