Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes

Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes

Variants in the phospholipase D3 (PLD3) gene have genetically been linked to late-onset Alzheimer's disease. We present a detailed biochemical analysis of PLD3 and reveal its endogenous localization in endosomes and lysosomes. PLD3 reaches lysosomes as a type II transmembrane protein via a (for...

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Bibliographic Details
Main Authors: Adriana Carolina Gonzalez, Michaela Schweizer, Sebastian Jagdmann, Christian Bernreuther, Thomas Reinheckel, Paul Saftig, Markus Damme
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cell Reports
Subjects:
phospholipase D3
PLD3
Alzheimer’s disease
ESCRT
lysosomes
ubiquitination
limited proteolysis
MVBs
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471731937X

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http://www.sciencedirect.com/science/article/pii/S221112471731937X

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