Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration

Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant Parkinson's disease (PD). The clinical and neurochemical features of LRRK2-linked PD are similar to idiopathic disease although neuropathology is somewhat heterogeneous. Dominant mutations in LRRK2 p...

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Bibliographic Details
Main Authors: Elpida Tsika, Meghna Kannan, Caroline Shi-Yan Foo, Dustin Dikeman, Liliane Glauser, Sandra Gellhaar, Dagmar Galter, Graham W. Knott, Ted M. Dawson, Valina L. Dawson, Darren J. Moore
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
LRRK2
PARK8
Dopaminergic
Nuclear envelope
Transgenic
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114002587

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http://www.sciencedirect.com/science/article/pii/S0969996114002587

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