Chronic bryostatin-1 rescues autistic and cognitive phenotypes in the fragile X mice

Abstract Fragile X syndrome (FXS), an X-chromosome linked intellectual disability, is the leading monogenetic cause of autism spectrum disorder (ASD), a neurodevelopmental condition that currently has no specific drug treatment. Building upon the demonstrated therapeutic effects on spatial memory of...

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Bibliographic Details
Main Authors: Patricia Cogram, Daniel L. Alkon, David Crockford, Robert M. J. Deacon, Michael J. Hurley, Francisco Altimiras, Miao-Kun Sun, Michael Tranfaglia
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-74848-6