Sticking With It: ER-PM Membrane Contact Sites as a Coordinating Nexus for Regulating Lipids and Proteins at the Cell Cortex

Sticking With It: ER-PM Membrane Contact Sites as a Coordinating Nexus for Regulating Lipids and Proteins at the Cell Cortex

Membrane contact sites between the cortical endoplasmic reticulum (ER) and the plasma membrane (PM) provide a direct conduit for small molecule transfer and signaling between the two largest membranes of the cell. Contact is established through ER integral membrane proteins that physically tether th...

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Bibliographic Details
Main Authors: Mohammad F. Zaman, Aleksa Nenadic, Ana Radojičić, Abel Rosado, Christopher T. Beh
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
endoplasmic reticulum
plasma membrane
ER-PM contact sites
membrane tethers
extended synaptotagmins
VAP (VAMP-associated protein)
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00675/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00675/full

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