mTHPC-loaded extracellular vesicles outperform liposomal and free mTHPC formulations by an increased stability, drug delivery efficiency and cytotoxic effect in tridimensional model of tumors

mTHPC-loaded extracellular vesicles outperform liposomal and free mTHPC formulations by an increased stability, drug delivery efficiency and cytotoxic effect in tridimensional model of tumors

Efficient photodynamic therapy with meta-tetra(hydroxyphenyl)chlorine requires the application of specific nanoformulations. mTHPC liposomal formulation (Foslip®) demonstrated favorable pharmacokinetics properties. However, rapid liposomes destruction in circulation and rapid mTHPC release impedes F...

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Bibliographic Details
Main Authors: Marie Millard, Ilya Yakavets, Max Piffoux, Amanda Brun, Florence Gazeau, Jean-Michel Guigner, Jordane Jasniewski, Henri-Pierre Lassalle, Claire Wilhelm, Lina Bezdetnaya
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Drug Delivery
Subjects:
mthpc
photodynamic therapy
multicellular tumor spheroid
extracellular vesicles
nanocarriers
Online Access:http://dx.doi.org/10.1080/10717544.2018.1513609

Internet

http://dx.doi.org/10.1080/10717544.2018.1513609

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