Therapeutic Vaccination of Hematopoietic Cell Transplantation Recipients Improves Protective CD8 T-Cell Immunotherapy of Cytomegalovirus Infection

Therapeutic Vaccination of Hematopoietic Cell Transplantation Recipients Improves Protective CD8 T-Cell Immunotherapy of Cytomegalovirus Infection

Reactivation of latent cytomegalovirus (CMV) endangers the therapeutic success of hematopoietic cell transplantation (HCT) in tumor patients due to cytopathogenic virus spread that leads to organ manifestations of CMV disease, to interstitial pneumonia in particular. In cases of virus variants that...

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Bibliographic Details
Main Authors: Kerstin M. Gergely, Jürgen Podlech, Sara Becker, Kirsten Freitag, Steffi Krauter, Nicole Büscher, Rafaela Holtappels, Bodo Plachter, Matthias J. Reddehase, Niels A. W. Lemmermann
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
adoptive cell transfer
antiviral protection
HCMV dense bodies
subviral particles
T cell receptor transgenic cells
T cell priming
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.694588/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.694588/full

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