Robustness and backbone motif of a cancer network regulated by miR-17-92 cluster during the G1/S transition.
Based on interactions among transcription factors, oncogenes, tumor suppressors and microRNAs, a Boolean model of cancer network regulated by miR-17-92 cluster is constructed, and the network is associated with the control of G1/S transition in the mammalian cell cycle. The robustness properties of...
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doaj-003e606d1f4d43768b05f5f46345df1c2020-11-25T02:19:47ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0183e5700910.1371/journal.pone.0057009Robustness and backbone motif of a cancer network regulated by miR-17-92 cluster during the G1/S transition.Lijian YangYan MengChun BaoWangheng LiuChengzhang MaAnbang LiZhan XuanGe ShanYa JiaBased on interactions among transcription factors, oncogenes, tumor suppressors and microRNAs, a Boolean model of cancer network regulated by miR-17-92 cluster is constructed, and the network is associated with the control of G1/S transition in the mammalian cell cycle. The robustness properties of this regulatory network are investigated by virtue of the Boolean network theory. It is found that, during G1/S transition in the cell cycle process, the regulatory networks are robustly constructed, and the robustness property is largely preserved with respect to small perturbations to the network. By using the unique process-based approach, the structure of this network is analyzed. It is shown that the network can be decomposed into a backbone motif which provides the main biological functions, and a remaining motif which makes the regulatory system more stable. The critical role of miR-17-92 in suppressing the G1/S cell cycle checkpoint and increasing the uncontrolled proliferation of the cancer cells by targeting a genetic network of interacting proteins is displayed with our model.http://europepmc.org/articles/PMC3585929?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lijian Yang Yan Meng Chun Bao Wangheng Liu Chengzhang Ma Anbang Li Zhan Xuan Ge Shan Ya Jia |
spellingShingle |
Lijian Yang Yan Meng Chun Bao Wangheng Liu Chengzhang Ma Anbang Li Zhan Xuan Ge Shan Ya Jia Robustness and backbone motif of a cancer network regulated by miR-17-92 cluster during the G1/S transition. PLoS ONE |
author_facet |
Lijian Yang Yan Meng Chun Bao Wangheng Liu Chengzhang Ma Anbang Li Zhan Xuan Ge Shan Ya Jia |
author_sort |
Lijian Yang |
title |
Robustness and backbone motif of a cancer network regulated by miR-17-92 cluster during the G1/S transition. |
title_short |
Robustness and backbone motif of a cancer network regulated by miR-17-92 cluster during the G1/S transition. |
title_full |
Robustness and backbone motif of a cancer network regulated by miR-17-92 cluster during the G1/S transition. |
title_fullStr |
Robustness and backbone motif of a cancer network regulated by miR-17-92 cluster during the G1/S transition. |
title_full_unstemmed |
Robustness and backbone motif of a cancer network regulated by miR-17-92 cluster during the G1/S transition. |
title_sort |
robustness and backbone motif of a cancer network regulated by mir-17-92 cluster during the g1/s transition. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2013-01-01 |
description |
Based on interactions among transcription factors, oncogenes, tumor suppressors and microRNAs, a Boolean model of cancer network regulated by miR-17-92 cluster is constructed, and the network is associated with the control of G1/S transition in the mammalian cell cycle. The robustness properties of this regulatory network are investigated by virtue of the Boolean network theory. It is found that, during G1/S transition in the cell cycle process, the regulatory networks are robustly constructed, and the robustness property is largely preserved with respect to small perturbations to the network. By using the unique process-based approach, the structure of this network is analyzed. It is shown that the network can be decomposed into a backbone motif which provides the main biological functions, and a remaining motif which makes the regulatory system more stable. The critical role of miR-17-92 in suppressing the G1/S cell cycle checkpoint and increasing the uncontrolled proliferation of the cancer cells by targeting a genetic network of interacting proteins is displayed with our model. |
url |
http://europepmc.org/articles/PMC3585929?pdf=render |
work_keys_str_mv |
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