Human Cytomegalovirus Immediate-Early 1 Protein Rewires Upstream STAT3 to Downstream STAT1 Signaling Switching an IL6-Type to an IFNγ-Like Response.

Human Cytomegalovirus Immediate-Early 1 Protein Rewires Upstream STAT3 to Downstream STAT1 Signaling Switching an IL6-Type to an IFNγ-Like Response.

The human cytomegalovirus (hCMV) major immediate-early 1 protein (IE1) is best known for activating transcription to facilitate viral replication. Here we present transcriptome data indicating that IE1 is as significant a repressor as it is an activator of host gene expression. Human cells induced t...

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Bibliographic Details
Main Authors: Thomas Harwardt, Simone Lukas, Marion Zenger, Tobias Reitberger, Daniela Danzer, Theresa Übner, Diane C Munday, Michael Nevels, Christina Paulus
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1005748

Internet

https://doi.org/10.1371/journal.ppat.1005748

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