Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk

Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk

This review integrates historical biochemical and modern genetic findings that underpin our understanding of the low-density lipoprotein (LDL) dyslipidemias that bear on human disease. These range from life-threatening conditions of infancy through severe coronary heart disease of young adulthood, t...

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Bibliographic Details
Main Authors: Sebastiano Calandra, Patrizia Tarugi, Helen E. Speedy, Andrew F. Dean, Stefano Bertolini, Carol C. Shoulders
Format: Article
Language:English
Published: Elsevier 2011-11-01
Series:Journal of Lipid Research
Subjects:
intestinal sterol absorption and efflux
cellular cholesterol synthesis
lipoprotein assembly
gallstones
LDL uptake
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520350811

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http://www.sciencedirect.com/science/article/pii/S0022227520350811

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