Monitoring circulating dipeptidyl peptidase 3 (DPP3) predicts improvement of organ failure and survival in sepsis: a prospective observational multinational study

Monitoring circulating dipeptidyl peptidase 3 (DPP3) predicts improvement of organ failure and survival in sepsis: a prospective observational multinational study

Abstract Background Dipeptidyl peptidase 3 (DPP3) is a cytosolic enzyme involved in the degradation of various cardiovascular and endorphin mediators. High levels of circulating DPP3 (cDPP3) indicate a high risk of organ dysfunction and mortality in cardiogenic shock patients. Methods The aim was to...

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Bibliographic Details
Main Authors: Alice Blet, Benjamin Deniau, Karine Santos, Dirk P. T. van Lier, Feriel Azibani, Xavier Wittebole, Benjamin G. Chousterman, Etienne Gayat, Oliver Hartmann, Joachim Struck, Andreas Bergmann, Massimo Antonelli, Albertus Beishuizen, Jean-Michel Constantin, Charles Damoisel, Nicolas Deye, Salvatore Di Somma, Thierry Dugernier, Bruno François, Stephane Gaudry, Vincent Huberlant, Jean-Baptiste Lascarrou, Gernot Marx, Emmanuelle Mercier, Haikel Oueslati, Peter Pickkers, Romain Sonneville, Matthieu Legrand, Pierre-François Laterre, Alexandre Mebazaa, AdrenOSS-1 Study Investigators
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Critical Care
Subjects:
DPP3
Biomarker
Outcome
Sepsis
Septic shock
Organ dysfunction
Online Access:https://doi.org/10.1186/s13054-021-03471-2

Internet

https://doi.org/10.1186/s13054-021-03471-2

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