Variable Domain N-Linked Glycans Acquired During Antigen-Specific Immune Responses Can Contribute to Immunoglobulin G Antibody Stability

Variable Domain N-Linked Glycans Acquired During Antigen-Specific Immune Responses Can Contribute to Immunoglobulin G Antibody Stability

Immunoglobulin G (IgG) can contain N-linked glycans in the variable domains, the so-called Fab glycans, in addition to the Fc glycans in the CH2 domains. These Fab glycans are acquired following introduction of N-glycosylation sites during somatic hypermutation and contribute to antibody diversifica...

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Bibliographic Details
Main Authors: Fleur S. van de Bovenkamp, Ninotska I. L. Derksen, Mariëlle J. van Breemen, Steven W. de Taeye, Pleuni Ooijevaar-de Heer, Rogier W. Sanders, Theo Rispens
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
antibody stability
variable domain glycosylation
Fab glycosylation
adalimumab
IVIg
thermal unfolding
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00740/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00740/full

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