Hypertrophy of Rat Skeletal Muscle Is Associated with Increased SIRT1/Akt/mTOR/S6 and Suppressed Sestrin2/SIRT3/FOXO1 Levels

Hypertrophy of Rat Skeletal Muscle Is Associated with Increased SIRT1/Akt/mTOR/S6 and Suppressed Sestrin2/SIRT3/FOXO1 Levels

Despite the intensive investigation of the molecular mechanism of skeletal muscle hypertrophy, the underlying signaling processes are not completely understood. Therefore, we used an overload model, in which the main synergist muscles (gastrocnemius, soleus) of the plantaris muscle were surgically r...

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Bibliographic Details
Main Authors: Zoltan Gombos, Erika Koltai, Ferenc Torma, Peter Bakonyi, Attila Kolonics, Dora Aczel, Tamas Ditroi, Peter Nagy, Takuji Kawamura, Zsolt Radak
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
overload-induced hypertrophy
skeletal muscle
anabolic signaling pathways
redox regulation
Online Access:https://www.mdpi.com/1422-0067/22/14/7588

Internet

https://www.mdpi.com/1422-0067/22/14/7588

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