Single-cell mass cytometry reveals complex myeloid cell composition in active lesions of progressive multiple sclerosis

Single-cell mass cytometry reveals complex myeloid cell composition in active lesions of progressive multiple sclerosis

Abstract Myeloid cells contribute to inflammation and demyelination in the early stages of multiple sclerosis (MS), but it is still unclear to what extent these cells are involved in active lesion formation in progressive MS (PMS). Here, we have harnessed the power of single-cell mass cytometry (CyT...

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Bibliographic Details
Main Authors: Chotima Böttcher, Marlijn van der Poel, Camila Fernández-Zapata, Stephan Schlickeiser, Julia K. H. Leman, Cheng-Chih Hsiao, Mark R. Mizee, Adelia, Maria C. J. Vincenten, Desiree Kunkel, Inge Huitinga, Jörg Hamann, Josef Priller
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Acta Neuropathologica Communications
Subjects:
Progressive multiple sclerosis
Mass cytometry
Microglia
Myeloid cells
Active lesion
Online Access:http://link.springer.com/article/10.1186/s40478-020-01010-8

Internet

http://link.springer.com/article/10.1186/s40478-020-01010-8

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