Application of amplicon-based targeted sequencing with the molecular barcoding system to detect uncommon minor EGFR mutations in patients with treatment-naïve lung adenocarcinoma

Application of amplicon-based targeted sequencing with the molecular barcoding system to detect uncommon minor EGFR mutations in patients with treatment-naïve lung adenocarcinoma

Abstract Background In lung cancer, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor sensitizing mutations co-existing with rare minor EGFR mutations are known as compound mutations. These minor EGFR mutations can lead to acquired resistance after EGFR tyrosine kinase inhibitor trea...

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Bibliographic Details
Main Authors: Kei Namba, Shuta Tomida, Takehiro Matsubara, Yuta Takahashi, Eisuke Kurihara, Yusuke Ogoshi, Takahiro Yoshioka, Tatsuaki Takeda, Hidejiro Torigoe, Hiroki Sato, Kazuhiko Shien, Hiromasa Yamamoto, Junichi Soh, Kazunori Tsukuda, Shinichi Toyooka
Format: Article
Language:English
Published: BMC 2019-02-01
Series:BMC Cancer
Subjects:
Non-small cell lung cancer
Epidermal growth factor receptor
Compound mutations
Molecular barcoding
Genomic heterogeneity
Patient genotype
Online Access:http://link.springer.com/article/10.1186/s12885-019-5374-1

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http://link.springer.com/article/10.1186/s12885-019-5374-1

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