Codon harmonization reduces amino acid misincorporation in bacterially expressed P. falciparum proteins and improves their immunogenicity

Codon harmonization reduces amino acid misincorporation in bacterially expressed P. falciparum proteins and improves their immunogenicity

Abstract Codon usage frequency influences protein structure and function. The frequency with which codons are used potentially impacts primary, secondary and tertiary protein structure. Poor expression, loss of function, insolubility, or truncation can result from species-specific differences in cod...

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Bibliographic Details
Main Authors: Neeraja Punde, Jennifer Kooken, Dagmar Leary, Patricia M. Legler, Evelina Angov
Format: Article
Language:English
Published: SpringerOpen 2019-10-01
Series:AMB Express
Subjects:
PfCelTOS
Codon-harmonization
Protein translation
Amino-acid misincorporation
Secondary structure
Alpha-helical content
Online Access:http://link.springer.com/article/10.1186/s13568-019-0890-6

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http://link.springer.com/article/10.1186/s13568-019-0890-6

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