Hepatic deficiency of the pioneer transcription factor FoxA restricts hepatitis B virus biosynthesis by the developmental regulation of viral DNA methylation.

Hepatic deficiency of the pioneer transcription factor FoxA restricts hepatitis B virus biosynthesis by the developmental regulation of viral DNA methylation.

The FoxA family of pioneer transcription factors regulates hepatitis B virus (HBV) transcription, and hence viral replication. Hepatocyte-specific FoxA-deficiency in the HBV transgenic mouse model of chronic infection prevents the transcription of the viral DNA genome as a result of the failure of t...

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Bibliographic Details
Main Authors: Vanessa C McFadden, Rasha E Shalaby, Saira Iram, Claudia E Oropeza, Jennifer A Landolfi, Alexander V Lyubimov, Mark Maienschein-Cline, Stefan J Green, Klaus H Kaestner, Alan McLachlan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1006239

Internet

https://doi.org/10.1371/journal.ppat.1006239

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