A kinetic model for Brain-Derived Neurotrophic Factor mediated spike timing-dependent LTP.

Across the mammalian nervous system, neurotrophins control synaptic plasticity, neuromodulation, and neuronal growth. The neurotrophin Brain-Derived Neurotrophic Factor (BDNF) is known to promote structural and functional synaptic plasticity in the hippocampus, the cerebral cortex, and many other br...

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Bibliographic Details
Main Authors: Sergio M G Solinas, Elke Edelmann, Volkmar Leßmann, Michele Migliore
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-04-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1006975