The Relationship between TP53 Gene Status and Carboxylesterase 2 Expression in Human Colorectal Cancer
Irinotecan (CPT-11) is an anticancer prodrug that is activated by the carboxylesterase CES2 and has been approved for the treatment of many types of solid tumors, including colorectal cancer. Recent studies with cell lines show that CES2 expression is regulated by the tumor suppressor protein p53. H...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2018-01-01
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| Series: | Disease Markers |
| Online Access: | http://dx.doi.org/10.1155/2018/5280736 |