Designs and Characterization of Subunit Ebola GP Vaccine Candidates: Implications for Immunogenicity

Designs and Characterization of Subunit Ebola GP Vaccine Candidates: Implications for Immunogenicity

The humoral responses of Ebola virus (EBOV) survivors mainly target the surface glycoprotein GP, and anti-GP neutralizing antibodies have been associated with protection against EBOV infection. In order to elicit protective neutralizing antibodies through vaccination a native-like conformation of th...

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Bibliographic Details
Main Authors: Valentina Agnolon, Divor Kiseljak, Maria J. Wurm, Florian M. Wurm, Charlotte Foissard, Fabrice Gallais, Sarah Wehrle, César Muñoz-Fontela, Laurent Bellanger, Bruno Emanuel Correia, Giampietro Corradin, François Spertini
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
Ebola virus
glycoprotein
Ebola glycoprotein
trimeric protein
vaccine
recombinant vaccine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.586595/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.586595/full

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