Detection of Replication Competent Lentivirus Using a qPCR Assay for VSV-G

Lentiviral vectors are a common tool used to introduce new and corrected genes into cell therapy products for treatment of human diseases. Although lentiviral vectors are ideal for delivery and stable integration of genes of interest into the host cell genome, they potentially pose risks to human he...

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Bibliographic Details
Main Authors: Lindsey M. Skrdlant, Randall J. Armstrong, Brett M. Keidaisch, Mario F. Lorente, David L. DiGiusto
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
PCR
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050117300980