Dithiolation indolizine exerts viability suppression effects on A549 cells via triggering intrinsic apoptotic pathways and inducing G2/M phase arrest

Dithiolation indolizine exerts viability suppression effects on A549 cells via triggering intrinsic apoptotic pathways and inducing G2/M phase arrest

Indolizine derivatives have been reported for the treatment of numerous diseases. However, few studies were carried out for non-small cell lung cancer (NSCLC). We synthesized series of indolizine compounds. The results of MTT assay showed compound 8 (C8) markedly inhibited the proliferation of A549...

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Bibliographic Details
Main Authors: Guanting Li, Xianwei Wu, Peng Sun, Zhiyang Zhang, Enxian Shao, Jianping Mao, Hua Cao, Hongliang Huang
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
A549 cells
Apoptosis
G2/M arrest
Endoplasmic reticulum stress (ERS)
Mitochondrial pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220311537

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http://www.sciencedirect.com/science/article/pii/S0753332220311537

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