Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis

Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis

Drug delivery in brain tumours is still a significant clinical concern. In this study, the authors develop a biomimetic lipoprotein nanoparticle for the efficient delivery of ATF5 siRNA inRas-activated brain cancer cells, where the nanoparticle is internalized by macropinocytosis in a Ras-dependent...

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Bibliographic Details
Main Authors: Jia-Lin Huang, Gan Jiang, Qing-Xiang Song, Xiao Gu, Meng Hu, Xiao-Lin Wang, Hua-Hua Song, Le-Pei Chen, Ying-Ying Lin, Di Jiang, Jun Chen, Jun-Feng Feng, Yong-Ming Qiu, Ji-Yao Jiang, Xin-Guo Jiang, Hong-Zhuan Chen, Xiao-Ling Gao
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15144

Internet

https://doi.org/10.1038/ncomms15144

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