Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis
Drug delivery in brain tumours is still a significant clinical concern. In this study, the authors develop a biomimetic lipoprotein nanoparticle for the efficient delivery of ATF5 siRNA inRas-activated brain cancer cells, where the nanoparticle is internalized by macropinocytosis in a Ras-dependent...
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Bibliographic Details
Main Authors: |
Jia-Lin Huang,
Gan Jiang,
Qing-Xiang Song,
Xiao Gu,
Meng Hu,
Xiao-Lin Wang,
Hua-Hua Song,
Le-Pei Chen,
Ying-Ying Lin,
Di Jiang,
Jun Chen,
Jun-Feng Feng,
Yong-Ming Qiu,
Ji-Yao Jiang,
Xin-Guo Jiang,
Hong-Zhuan Chen,
Xiao-Ling Gao |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2017-05-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/ncomms15144
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