Use of metformin alone is not associated with survival outcomes of colorectal cancer cell but AMPK activator AICAR sensitizes anticancer effect of 5-fluorouracil through AMPK activation.

Use of metformin alone is not associated with survival outcomes of colorectal cancer cell but AMPK activator AICAR sensitizes anticancer effect of 5-fluorouracil through AMPK activation.

Colorectal cancer (CRC) is still the third most common cancer and the second most common causes of cancer-related death around the world. Metformin, a biguanide, which is widely used for treating diabetes mellitus, has recently been shown to have a suppressive effect on CRC risk and mortality, but n...

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Bibliographic Details
Main Authors: Xinbing Sui, Yinghua Xu, Jie Yang, Yong Fang, Haizhou Lou, Weidong Han, Maolin Zhang, Wei Chen, Kaifeng Wang, Da Li, Wei Jin, Fang Lou, Yu Zheng, Hong Hu, Liu Gong, Xiaoyun Zhou, Qin Pan, Hongming Pan, Xian Wang, Chao He
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4029793?pdf=render

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http://europepmc.org/articles/PMC4029793?pdf=render

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