Bullatacin Triggered ABCB1-Overexpressing Cell Apoptosis via the Mitochondrial-Dependent Pathway

This paper was to explore bullatacin-mediated multidrug-resistant cell apoptosis at extremely low concentration. To investigate its precise mechanisms, the pathway of cell apoptosis induced by bullatacin was examined. Bullatacin causes an upregulation of ROS and a downregulation of ΔΨm in a concent...

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Bibliographic Details
Main Authors: Yong-Ju Liang, Xu Zhang, Chun-Ling Dai, Jian-Ye Zhang, Yan-Yan Yan, Mu-Sheng Zeng, Li-Ming Chen, Li-Wu Fu
Format: Article
Language:English
Published: Hindawi Limited 2009-01-01
Series:Journal of Biomedicine and Biotechnology
Online Access:http://dx.doi.org/10.1155/2009/867123