Vaccine-Mediated Mechanisms Controlling Replication of Francisella tularensis in Human Peripheral Blood Mononuclear Cells Using a Co-culture System

Vaccine-Mediated Mechanisms Controlling Replication of Francisella tularensis in Human Peripheral Blood Mononuclear Cells Using a Co-culture System

Cell-mediated immunity (CMI) is normally required for efficient protection against intracellular infections, however, identification of correlates is challenging and they are generally lacking. Francisella tularensis is a highly virulent, facultative intracellular bacterium and CMI is critically req...

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Bibliographic Details
Main Authors: Kjell Eneslätt, Igor Golovliov, Patrik Rydén, Anders Sjöstedt
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
F. tularensis
in vitro model
human immune response
IFN-γ
TNF
MIP-1β
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2018.00027/full

Internet

http://journal.frontiersin.org/article/10.3389/fcimb.2018.00027/full

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