The Response to DNA Damage at Telomeric Repeats and Its Consequences for Telomere Function

The Response to DNA Damage at Telomeric Repeats and Its Consequences for Telomere Function

Telomeric repeats, coated by the shelterin complex, prevent inappropriate activation of the DNA damage response at the ends of linear chromosomes. Shelterin has evolved distinct solutions to protect telomeres from different aspects of the DNA damage response. These solutions include formation of t-l...

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Bibliographic Details
Main Author: Ylli Doksani
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Genes
Subjects:
telomere maintenance
shelterin complex
end-protection problem
telomere damage
telomeric double strand breaks
telomere replication
alternative lengthening of telomeres
Online Access:https://www.mdpi.com/2073-4425/10/4/318

Internet

https://www.mdpi.com/2073-4425/10/4/318

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