The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin

The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin

AGAP1 is an Arf1 GTPase activating protein that interacts with the vesicle-associated protein complexes adaptor protein 3 (AP-3) and Biogenesis of Lysosome Related Organelles Complex-1 (BLOC-1). Overexpression of AGAP1 in non-neuronal cells results in an accumulation of endosomal cargoes, which sugg...

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Bibliographic Details
Main Authors: Miranda Arnold, Rebecca Cross, Kaela S Singleton, Stephanie Zlatic, Ariana P Mullin, Christopher Chapleau, Isaiah Rolle, Carlene Moore, Anne Theibert, Lucas Pozzo-Miller, Victor Faundez, Jennifer Larimore
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Dendritic Spines
Schizophrenia
autism
endosome
ARF-GAP
dysbindin
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00218/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00218/full

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