A novel Huntington's disease mouse model to assess the role of neuroinflammation on disease progression and to develop human cell therapies

A novel Huntington's disease mouse model to assess the role of neuroinflammation on disease progression and to develop human cell therapies

Abstract Huntington's disease (HD) is a fatal autosomal‐dominant neurodegenerative disease caused by a trinucleotide CAG repeat expansion of the huntingtin gene (HTT) that affects 1 in every 10 000 individuals in the United States. Our lab developed a novel immune deficient HD mouse strain, the...

Full description

Bibliographic Details
Main Authors: Heather Dahlenburg, David Cameron, Sheng Yang, Angelica Bachman, Kari Pollock, Whitney Cary, Missy Pham, Kyle Hendrix, Jeannine White, Haley Nelson, Peter Deng, Joseph S. Anderson, Kyle Fink, Jan Nolta
Format: Article
Language:English
Published: Wiley 2021-07-01
Series:Stem Cells Translational Medicine
Subjects:
humanization
Huntington's disease
mouse model
neuroinflammation
stem cells
Online Access:https://doi.org/10.1002/sctm.20-0431

Internet

https://doi.org/10.1002/sctm.20-0431

Similar Items