A randomized placebo controlled clinical trial to evaluate the efficacy and safety of minocycline in patients with Angelman syndrome (A-MANECE study)

A randomized placebo controlled clinical trial to evaluate the efficacy and safety of minocycline in patients with Angelman syndrome (A-MANECE study)

Abstract Background Minocycline is an old tetracycline antibiotic that has shown antiinflammatory and antiapoptotic properties in different neurological disease mouse models. Previous single arm study in humans demonstrated benefits in individuals with Angelman Syndrome (AS); however, its efficacy i...

Full description

Bibliographic Details
Main Authors: Belén Ruiz-Antoran, Aranzazu Sancho-López, Rosario Cazorla-Calleja, Luis Fernando López-Pájaro, Ágata Leiva, Gema Iglesias-Escalera, Maria Esperanza Marín-Serrano, Marta Rincón-Ortega, Julián Lara-Herguedas, Teresa Rossignoli-Palomeque, Sara Valiente-Rodríguez, Javier González-Marques, Enriqueta Román-Riechmann, Cristina Avendaño-Solá
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Orphanet Journal of Rare Diseases
Subjects:
Angelman syndrome
Treatment
Minocycline
Developmental changes
Pharmacological intervention
Online Access:http://link.springer.com/article/10.1186/s13023-018-0891-6

Internet

http://link.springer.com/article/10.1186/s13023-018-0891-6

Similar Items