Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma

Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma

Caspase-8 is a key player in extrinsic apoptosis and its activity is often downregulated in cancer. However, human Caspase-8 expression is retained in some tumors, including glioblastoma (GBM), suggesting that it may support cancer growth in these contexts. GBM, the most aggressive of the gliomas, i...

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Bibliographic Details
Main Authors: Giulia Fianco, Maria Patrizia Mongiardi, Andrea Levi, Teresa De Luca, Marianna Desideri, Daniela Trisciuoglio, Donatella Del Bufalo, Irene Cinà, Anna Di Benedetto, Marcella Mottolese, Antonietta Gentile, Diego Centonze, Fabrizio Ferrè, Daniela Barilà
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-06-01
Series:eLife
Subjects:
mouse
cell death
cell proliferation
signal transduction
cancer
angiogenesis
Online Access:https://elifesciences.org/articles/22593

Internet

https://elifesciences.org/articles/22593

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