Integrated Approach Reveals Role of Mitochondrial Germ-Line Mutation F18L in Respiratory Chain, Oxidative Alterations, Drug Sensitivity, and Patient Prognosis in Glioblastoma

Integrated Approach Reveals Role of Mitochondrial Germ-Line Mutation F18L in Respiratory Chain, Oxidative Alterations, Drug Sensitivity, and Patient Prognosis in Glioblastoma

Glioblastoma is the most common and malignant primary brain tumour in adults, with a dismal prognosis. This is partly due to considerable inter- and intra-tumour heterogeneity. Changes in the cellular energy-producing mitochondrial respiratory chain complex (MRC) activities are a hallmark of gliobla...

Full description

Bibliographic Details
Main Authors: Kathleen Keatley, Samuel Stromei-Cleroux, Tammy Wiltshire, Nina Rajala, Gary Burton, William V. Holt, D. Timothy J. Littlewood, Andrew G. Briscoe, Josephine Jung, Keyoumars Ashkan, Simon J. Heales, Geoffrey J. Pilkington, Brigitte Meunier, John E. McGeehan, Iain P. Hargreaves, Rhiannon E. McGeehan
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
glioblastoma
mtDNA
mutation
mitochondria
OXPHOS
ROS
CoQ10
prognosis
clomipramine
Online Access:https://www.mdpi.com/1422-0067/20/13/3364

Internet

https://www.mdpi.com/1422-0067/20/13/3364

Similar Items