Fine-scale variation and genetic determinants of alternative splicing across individuals.

Recently, thanks to the increasing throughput of new technologies, we have begun to explore the full extent of alternative pre-mRNA splicing (AS) in the human transcriptome. This is unveiling a vast layer of complexity in isoform-level expression differences between individuals. We used previously p...

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Bibliographic Details
Main Authors: Jasmin Coulombe-Huntington, Kevin C L Lam, Christel Dias, Jacek Majewski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-12-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2780703?pdf=render