Systemic gene delivery to the central nervous system using Adeno-associated virus

Systemic gene delivery to the central nervous system using Adeno-associated virus

Adeno-associated virus (AAV)-mediated gene delivery has emerged as an effective and safe tool for both preclinical and clinical studies of neurological disorders. The recent discovery that several serotypes are able to cross the blood-brain-barrier when administered systemically has been a real brea...

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Bibliographic Details
Main Authors: Mathieu eBOURDENX, Nathalie eDUTHEIL, Erwan eBEZARD, Benjamin eDEHAY
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Injections
neurological disorders
gene therapy for neurodegenerative diseases
AAV vectors
Models, Biological
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00050/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00050/full

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