Altered intrathalamic GABAA neurotransmission in a mouse model of a human genetic absence epilepsy syndrome

Altered intrathalamic GABAA neurotransmission in a mouse model of a human genetic absence epilepsy syndrome

We previously demonstrated that heterozygous deletion of Gabra1, the mouse homolog of the human absence epilepsy gene that encodes the GABAA receptor (GABAAR) α1 subunit, causes absence seizures. We showed that cortex partially compensates for this deletion by increasing the cell surface expression...

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Bibliographic Details
Main Authors: Chengwen Zhou, Li Ding, M. Elizabeth Deel, Elizabeth A. Ferrick, Ronald B. Emeson, Martin J. Gallagher
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Neurobiology of Disease
Subjects:
Biotinylation
Brain
Confocal microscopy
Electrophysiology
Epilepsy
GABA
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114003349

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http://www.sciencedirect.com/science/article/pii/S0969996114003349

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