A stalled-ribosome rescue factor Pth3 is required for mitochondrial translation against antibiotics in Saccharomyces cerevisiae

A stalled-ribosome rescue factor Pth3 is required for mitochondrial translation against antibiotics in Saccharomyces cerevisiae

Hoshino et al. show that PTH3, the S. cerevisiae homolog of C12orf65, is required for the translation of mitochondrial genes in the presence of antibiotics. This study suggests that PTH3 rescues the ribosomes stalled by antibiotics, playing a role in antibiotic resistance in fungi.

Bibliographic Details
Main Authors: Soichiro Hoshino, Ryohei Kanemura, Daisuke Kurita, Yukihiro Soutome, Hyouta Himeno, Masak Takaine, Masakatsu Watanabe, Nobukazu Nameki
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-01835-6

Internet

https://doi.org/10.1038/s42003-021-01835-6

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