The expression of the beta cell-derived autoimmune ligand for the killer receptor nkp46 is attenuated in type 2 diabetes.

The expression of the beta cell-derived autoimmune ligand for the killer receptor nkp46 is attenuated in type 2 diabetes.

NK cells rapidly kill tumor cells, virus infected cells and even self cells. This is mediated via killer receptors, among which NKp46 (NCR1 in mice) is prominent. We have recently demonstrated that in type 1 diabetes (T1D) NK cells accumulate in the diseased pancreas and that they manifest a hypores...

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Bibliographic Details
Main Authors: Chamutal Gur, Jonatan Enk, Efraim Weitman, Etty Bachar, Yaron Suissa, Guy Cohen, Rachel Ben-Haroush Schyr, Helena Sabanay, Elad Horwitz, Benjamin Glaser, Yuval Dor, Ariel Pribluda, Jacob H Hanna, Gill Leibowitz, Ofer Mandelboim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3757008?pdf=render

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http://europepmc.org/articles/PMC3757008?pdf=render

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