Efficient production of (R)-2-hydroxy-4-phenylbutyric acid by using a coupled reconstructed D-lactate dehydrogenase and formate dehydrogenase system.

Efficient production of (R)-2-hydroxy-4-phenylbutyric acid by using a coupled reconstructed D-lactate dehydrogenase and formate dehydrogenase system.

<h4>Background</h4>(R)-2-hydroxy-4-phenylbutyric acid [(R)-HPBA] is a key precursor for the production of angiotensin-converting enzyme inhibitors. However, the product yield and concentration of reported (R)-HPBA synthetic processes remain unsatisfactory.<h4>Methodology/principal...

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Bibliographic Details
Main Authors: Binbin Sheng, Zhaojuan Zheng, Min Lv, Haiwei Zhang, Tong Qin, Chao Gao, Cuiqing Ma, Ping Xu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25089519/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25089519/?tool=EBI

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