Annexin A1 protects against cerebral ischemia–reperfusion injury by modulating microglia/macrophage polarization via FPR2/ALX-dependent AMPK-mTOR pathway

Annexin A1 protects against cerebral ischemia–reperfusion injury by modulating microglia/macrophage polarization via FPR2/ALX-dependent AMPK-mTOR pathway

Abstract Background Cerebral ischemia–reperfusion (I/R) injury is a major cause of early complications and unfavorable outcomes after endovascular thrombectomy (EVT) therapy in patients with acute ischemic stroke (AIS). Recent studies indicate that modulating microglia/macrophage polarization and su...

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Bibliographic Details
Main Authors: Xin Xu, Weiwei Gao, Lei Li, Jiheng Hao, Bin Yang, Tao Wang, Long Li, Xuesong Bai, Fanjian Li, Honglei Ren, Meng Zhang, Liyong Zhang, Jiyue Wang, Dong Wang, Jianning Zhang, Liqun Jiao
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Journal of Neuroinflammation
Subjects:
Cerebral ischemia-reperfusion injury
Endovascular thrombectomy
Neuroinflammation
Microglial/macrophage polarization
Annexin A1
Formyl peptide receptor 2
Online Access:https://doi.org/10.1186/s12974-021-02174-3

Internet

https://doi.org/10.1186/s12974-021-02174-3

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