Inhibition of c-Abl kinase activity renders cancer cells highly sensitive to mitoxantrone.

Inhibition of c-Abl kinase activity renders cancer cells highly sensitive to mitoxantrone.

Although c-Abl has increasingly emerged as a key player in the DNA damage response, its role in this context is far from clear. We studied the effect of inhibition of c-Abl kinase activity by imatinib with chemotherapy drugs and found a striking difference in cell survival after combined mitoxantron...

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Bibliographic Details
Main Authors: Kemal Alpay, Mehdi Farshchian, Johanna Tuomela, Jouko Sandholm, Kaappo Aittokallio, Elina Siljamäki, Marko Kallio, Veli-Matti Kähäri, Sakari Hietanen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4141754?pdf=render

Internet

http://europepmc.org/articles/PMC4141754?pdf=render

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