A pre-existing population of ZEB2+ quiescent cells with stemness and mesenchymal features dictate chemoresistance in colorectal cancer

A pre-existing population of ZEB2+ quiescent cells with stemness and mesenchymal features dictate chemoresistance in colorectal cancer

Abstract Background Quiescent/slow cycling cells have been identified in several tumors and correlated with therapy resistance. However, the features of chemoresistant populations and the molecular factors linking quiescence to chemoresistance are largely unknown. Methods A population of chemoresist...

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Bibliographic Details
Main Authors: Federica Francescangeli, Paola Contavalli, Maria Laura De Angelis, Silvia Careccia, Michele Signore, Tobias Longin Haas, Federico Salaris, Marta Baiocchi, Alessandra Boe, Alessandro Giuliani, Olga Tcheremenskaia, Alfredo Pagliuca, Ombretta Guardiola, Gabriella Minchiotti, Lidia Colace, Antonio Ciardi, Vito D’Andrea, Filippo La Torre, JanPaul Medema, Ruggero De Maria, Ann Zeuner
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Colorectal cancer
Chemotherapy resistance
Dormancy
Quiescence
Epithelial-to-mesenchymal transition
Cancer stem cells
Online Access:https://doi.org/10.1186/s13046-019-1505-4

Internet

https://doi.org/10.1186/s13046-019-1505-4

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