Pharmacological Regulation of Neuropathic Pain Driven by Inflammatory Macrophages

Pharmacological Regulation of Neuropathic Pain Driven by Inflammatory Macrophages

Neuropathic pain can have a major effect on quality of life but current therapies are often inadequate. Growing evidence suggests that neuropathic pain induced by nerve damage is caused by chronic inflammation. Upon nerve injury, damaged cells secrete pro-inflammatory molecules that activate cells i...

Full description

Bibliographic Details
Main Authors:	Norikazu Kiguchi, Daichi Kobayashi, Fumihiro Saika, Shinsuke Matsuzaki, Shiroh Kishioka
Format:	Article
Language:	English
Published:	MDPI AG 2017-11-01
Series:	International Journal of Molecular Sciences
Subjects:	cytokine chemokine leukocyte neutrophil neuroinflammation allodynia hyperalgesia nicotinic acetylcholine receptor
Online Access:	https://www.mdpi.com/1422-0067/18/11/2296

Similar Items

Inhibition of peripheral macrophages by nicotinic acetylcholine receptor agonists suppresses spinal microglial activation and neuropathic pain in mice with peripheral nerve injury
by: Norikazu Kiguchi, et al.
Published: (2018-03-01)

Peripheral administration of interleukin-13 reverses inflammatory macrophage and tactile allodynia in mice with partial sciatic nerve ligation
by: Norikazu Kiguchi, et al.
Published: (2017-01-01)

TC-2559, an α4β2 nicotinic acetylcholine receptor agonist, suppresses the expression of CCL3 and IL-1β through STAT3 inhibition in cultured murine macrophages
by: Norikazu Kiguchi, et al.
Published: (2015-06-01)

Chemogenetic Regulation of CX3CR1-Expressing Microglia Using Gi-DREADD Exerts Sex-Dependent Anti-Allodynic Effects in Mouse Models of Neuropathic Pain
by: Fumihiro Saika, et al.
Published: (2020-06-01)

Chemogenetic Activation of CX3CR1-Expressing Spinal Microglia Using Gq-DREADD Elicits Mechanical Allodynia in Male Mice
by: Fumihiro Saika, et al.
Published: (2021-04-01)

Developmental Changes In Pain And Spinal Immune Gene Expression After Radicular Trauma In The Rat
by: Gordon Alfred Barr, et al.
Published: (2016-12-01)

Epigenetic regulation of CC-chemokine ligand 2 in nonresolving inflammation
by: Kiguchi Norikazu, et al.
Published: (2014-08-01)

Effect of ethosucximide on the reduction of neuropathic pain due to chronic constriction of the sciatic nerve in rats
by: Gholam Ali Hamidi, et al.
Published: (2013-05-01)

The role of NMDA receptors in the effects of corticosterone on CCI model neuropathic pain in rats
by: S. Faryadian, et al.
Published: (2008-05-01)

Effect of biotin supplementation on neuropathic pain induced by chronic constriction of the sciatic nerve in the rat
by: Ali-Reza Abed, et al.
Published: (2021-01-01)

Influence of verapmil on the inhibitory effects of corticosterone on neuropathic pain behaviors in rats
by: Sara Faryadian, et al.
Published: (2008-11-01)

Permanent relief from intermittent cold stress-induced fibromyalgia-like abnormal pain by repeated intrathecal administration of antidepressants
by: Mukae Takehiro, et al.
Published: (2011-09-01)

Analgesic Effect of Harpagophytum procumbens on Postoperative and Neuropathic Pain in Rats
by: Dong Wook Lim, et al.
Published: (2014-01-01)

Synaptotagmin 1 Is Involved in Neuropathic Pain and Electroacupuncture-Mediated Analgesic Effect
by: Juan Wan, et al.
Published: (2020-01-01)

Age-Related Differences in Neuropathic Pain Behavior and Spinal Microglial Activity after L5 Spinal Nerve Ligation in Male Rats
by: Hossien Zeinali, et al.
Published: (2016-07-01)

The potential role of neuropathic mechanisms in dry eye syndromes
by: Charles W. Mcmonnies
Published: (2017-01-01)

Study of the effect of GABAA receptore and glial inhibition on behavioral responses in CCI model of neuropathic pain in rat
by: Mehi Sadeghi, et al.
Published: (2015-01-01)

The evaluation of role of NMDA receptor and spinal microglia on age dependent differences of neuropathic pain in SNL model in male rats
by: Hussain zeinali, et al.
Published: (2015-04-01)

The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CB<sub>2</sub> receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy
by: Deng Liting, et al.
Published: (2012-09-01)

The Potential Role of Glycogen Synthase Kinase-3β in Neuropathy-Induced Apoptosis in Spinal Cord
by: Mina Rashvand, et al.
Published: (2020-01-01)

Activation of neurotrophins in lumbar dorsal root probably contributes to neuropathic pain after spinal nerve ligation
by: Abdolreza Kazemi, et al.
Published: (2017-01-01)

Targeting the endogenous cannabinoid system to treat chronic neuropathic pain
by: Benjamin K Lau, et al.
Published: (2014-03-01)

Protective effect of Rubia cordifolia in paclitaxel-induced neuropathic pain in experimental animals
by: Chaitali Diwane, et al.
Published: (2015-01-01)

Evaluation of Analgesic Effects of Hydroalcoholic Extract of Allium cepa L. in Animal Model of Neuropathic Pain
by: Sanaz Mahdipour, et al.
Published: (2017-05-01)

Allodynia and hyperalgesia: review
by: K. D. Dmytriiev, et al.
Published: (2018-09-01)

Nociceptive Effects of Locally Treated Metoprolol
by: Nursima Cukadar, et al.
Published: (2015-06-01)

The effect of turmeric and curcumin on neuropathic pain behavioral response of CCI model in rats
by: Hossein Ali Safakhah, et al.
Published: (2020-09-01)

GPR34 in spinal microglia exacerbates neuropathic pain in mice
by: Akira Sayo, et al.
Published: (2019-04-01)

Allosterism of Nicotinic Acetylcholine Receptors: Therapeutic Potential for Neuroinflammation Underlying Brain Trauma and Degenerative Disorders
by: Swarup Mitra, et al.
Published: (2020-07-01)

Anti-hyperalgesic properties of a flavanone derivative Poncirin in acute and chronic inflammatory pain models in mice
by: Ruqayya Afridi, et al.
Published: (2019-09-01)

Dietary Supplementation with Palmitoyl-Glucosamine Co-Micronized with Curcumin Relieves Osteoarthritis Pain and Benefits Joint Mobility
by: Enrico Gugliandolo, et al.
Published: (2020-10-01)

Antihyperalgesic Properties of Honokiol in Inflammatory Pain Models by Targeting of NF-κB and Nrf2 Signaling
by: Sidra Khalid, et al.
Published: (2018-03-01)

Analgesic strategies aimed at stimulating the endogenous production of allopregnanolone
by: Pierrick ePoisbeau, et al.
Published: (2014-06-01)

The Edible Brown Seaweed Ecklonia cava Reduces Hypersensitivity in Postoperative and Neuropathic Pain Models in Rats
by: Jae Goo Kim, et al.
Published: (2014-06-01)

Effect of Gabapentin and Pregabalin in Rat Model of Taxol Induced Neuropathic Pain
by: A.Mangaiarkkarasi, et al.
Published: (2015-05-01)

Zerumbone-Induced Analgesia Modulated via Potassium Channels and Opioid Receptors in Chronic Constriction Injury-Induced Neuropathic Pain
by: Banulata Gopalsamy, et al.
Published: (2020-08-01)

Biochanin-A attenuates neuropathic pain in diabetic rats
by: Venkateswarlu Chundi, et al.
Published: (2016-10-01)

Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress
by: Dan Zhao, et al.
Published: (2017-12-01)

Does Cholinergic Stimulation Affect the P2X7 Receptor-Mediated Dye Uptake in Mast Cells and Macrophages?
by: Dilyara Nurkhametova, et al.
Published: (2020-10-01)

Co-administration of human adipose-derived stem cells and low-level laser to alleviate neuropathic pain after experimental spinal cord injury
by: Arash Sarveazad, et al.
Published: (2019-06-01)