Inhibition of Murine Breast Cancer Metastases by Hydrophilic As4S4 Nanoparticles Is Associated With Decreased ROS and HIF-1α Downregulation

Inhibition of Murine Breast Cancer Metastases by Hydrophilic As4S4 Nanoparticles Is Associated With Decreased ROS and HIF-1α Downregulation

Arsenic sulfide (As4S4) is a mineral drug that can be administrated orally and has been applied in the treatment of myeloid leukemia. The aim of this work is to investigate the therapeutic effect of As4S4 in highly metastatic triple-negative breast cancer (TNBC) animal model, as As4S4 has not been a...

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Bibliographic Details
Main Authors: Tao Wang, Jie Meng, Chuan Wang, Tao Wen, Mengfan Jia, Yangyang Ge, Lifei Xie, Suisui Hao, Jian Liu, Haiyan Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Oncology
Subjects:
breast cancer
As4S4 nanoparticles
reactive oxygen species
hypoxic tumor microenvironment
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00333/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.00333/full

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