Safe Synthesis of 4,7-Dibromo[1,2,5]thiadiazolo[3,4-d]pyridazine and Its SNAr Reactions

Safe Synthesis of 4,7-Dibromo[1,2,5]thiadiazolo[3,4-d]pyridazine and Its SNAr Reactions

A safe and efficient synthesis of 4,7-dibromo[1,2,5]thiadiazolo[3,4-d]pyridazine from the commercial diaminomaleonitrile is reported. Conditions for selective aromatic nucleophilic substitution of one or two bromine atoms by oxygen and nitrogen nucleophiles are found, whereas thiols formed the bis-d...

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Bibliographic Details
Main Authors: Timofey N. Chmovzh, Ekaterina A. Knyazeva, Konstantin A. Lyssenko, Vadim V. Popov, Oleg A. Rakitin
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Molecules
Subjects:
sulfur-nitrogen heterocycles
[1,2,5]thiadiazolo[3,4-d]pyridazine
aromatic nucleophilic substitution
X-ray analysis
Online Access:http://www.mdpi.com/1420-3049/23/10/2576

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http://www.mdpi.com/1420-3049/23/10/2576

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