Cross-talk between canonical Wnt signaling and the sirtuin-FoxO longevity pathway to protect against muscular pathology induced by mutant PABPN1 expression in C. elegans

Cross-talk between canonical Wnt signaling and the sirtuin-FoxO longevity pathway to protect against muscular pathology induced by mutant PABPN1 expression in C. elegans

Developmental pathways may be play a role in adult cell survival. However, whether they interact with longevity/cell survival pathways to confer protection against disease-associated proteotoxicity remains largely unknown. We previously reported that the inhibition of key longevity modulators such a...

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Bibliographic Details
Main Authors: Matthieu Y. Pasco, Hélène Catoire, J. Alex Parker, Bernard Brais, Guy A. Rouleau, Christian Néri
Format: Article
Language:English
Published: Elsevier 2010-06-01
Series:Neurobiology of Disease
Subjects:
Muscular dystrophy
PABPN1
Intracellular signaling
Cell survival
C. elegans
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611000063X

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http://www.sciencedirect.com/science/article/pii/S096999611000063X

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