CB2 cannabinoid receptors contribute to bacterial invasion and mortality in polymicrobial sepsis.

BACKGROUND:Sepsis is a major healthcare problem and current estimates suggest that the incidence of sepsis is approximately 750,000 annually. Sepsis is caused by an inability of the immune system to eliminate invading pathogens. It was recently proposed that endogenous mediators produced during seps...

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Main Authors: Balázs Csóka, Zoltán H Németh, Partha Mukhopadhyay, Zoltán Spolarics, Mohanraj Rajesh, Stephanie Federici, Edwin A Deitch, Sándor Bátkai, Pál Pacher, György Haskó
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2712683?pdf=render