Cariprazine, A Dopamine D2/D3 Receptor Partial Agonist, Modulates ABCG2-Mediated Multidrug Resistance in Cancer

Cariprazine, A Dopamine D2/D3 Receptor Partial Agonist, Modulates ABCG2-Mediated Multidrug Resistance in Cancer

Multidrug resistance (MDR) is a continuing clinical problem that limits the efficacy of chemotherapy in cancer. The over expression of the ATP-binding cassette (ABC) family G2 (ABCG2) transporter is one of the main mechanisms that mediates MDR in cancer. Molecular modeling data indicated that caripr...

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Bibliographic Details
Main Authors: Noor Hussein, Charles R. Ashby, Haneen Amawi, Angelique Nyinawabera, Atul Vij, Vishwa M. Khare, Chandrabose Karthikeyan, Amit K. Tiwari
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Cancers
Subjects:
ABCG2
Cariprazine
Colon cancer
Lung cancer
Dopamine D3-preferring D2/D3 receptor partial
Multidrug resistance
Online Access:http://www.mdpi.com/2072-6694/10/9/308

Internet

http://www.mdpi.com/2072-6694/10/9/308

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