Impact of molecular weight on the mechanism of cellular uptake of polyethylene glycols (PEGs) with particular reference to P-glycoprotein

Impact of molecular weight on the mechanism of cellular uptake of polyethylene glycols (PEGs) with particular reference to P-glycoprotein

Polyethylene glycols (PEGs) in general use are polydisperse molecules with molecular weight (MW) distributed around an average value applied in their designation e.g., PEG 4000. Previous research has shown that PEGs can act as P-glycoprotein (P-gp) inhibitors with the potential to affect the absorpt...

Full description

Bibliographic Details
Main Authors: Tingting Wang, Yingjie Guo, Yang He, Tianming Ren, Lei Yin, John Paul Fawcett, Jingkai Gu, Huimin Sun
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Acta Pharmaceutica Sinica B
Subjects:
P-gp
PEGs
P-gp-substrate
Passive diffusion
Endocytosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383519314613

Internet

http://www.sciencedirect.com/science/article/pii/S2211383519314613

Similar Items