Suppression of Transmembrane Tumor Necrosis Factor Alpha Processing by a Specific Antibody Protects Against Colitis-Associated Cancer

Suppression of Transmembrane Tumor Necrosis Factor Alpha Processing by a Specific Antibody Protects Against Colitis-Associated Cancer

Soluble tumor necrosis factor-α (sTNF-α) plays an important role in colitis-associated cancer (CAC); however, little is known about transmembrane TNF-α (tmTNF-α). Here, we observed an increase in sTNF-α mainly in colitis tissues from an azoxymethane/dextran sodium sulfate (DSS)-induced CAC mouse mod...

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Bibliographic Details
Main Authors: Hongping Ba, Rui Jiang, Meng Zhang, Bingjiao Yin, Jing Wang, Zhuoya Li, Baihua Li, Xiaoxi Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
transmembrane tumor necrosis factor-α
soluble tumor necrosis factor-α
colitis-associated cancer
antibody-based therapy
cytokines
macrophages
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.687874/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.687874/full

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